Fertility Decoded

PGT-A (preimplantation genetic testing for aneuploidy)

A biopsy of the embryo to check it has the right number of chromosomes before transfer.

Written by Fertility Decoded. Reviewed by D R, MS (OBG), FRM. Review date: 31 August 2026.

The verdict

Not recommended as a routine add-on; it may reduce your chance of a baby (especially under 35), though it can reduce the chance of miscarriage.

Who are these bodies?

HFEA
— UK fertility regulator; rates add-ons by evidence (traffic-light).
ESHRE
— European fertility society; evidence-based practice guidance.
NICE
— UK health-guidance body; what the NHS will and won't fund.
ISAR
— Indian Society for Assisted Reproduction; Indian expert consensus.
Cochrane
— Independent global reviewers of the underlying studies.

  • HFEA

    UK regulator

    Red — may reduce effectiveness — chance of a baby (most patients)Green — effective — reducing miscarriage (most patients)Grey — insufficient evidence — either outcome in older women
    Source

  • ESHRE

    European society

    Not for routine use

    Not recommended for routine clinical use; specific groups (e.g. older patients) may benefit, but routine use isn't recommended without more evidence.

    Source

  • NICE

    UK NHS guidance

    Do not offer (2026)

    NG257 1.48.1: do not offer PGT-A as part of fertility treatment to improve live birth rates.

    Source

  • ISAR

    Indian society

    Role for age 36–40 & known-cause RPL

    ISAR PGT consensus: recommended for advanced maternal age (36–40) and repeated pregnancy loss with a known cause; not recommended for under-35 good-prognosis, unexplained RPL, or low-AMH patients; no evidence of efficacy in recurrent implantation failure.

    Source

  • Cochrane

    Evidence base

    2020 review: insufficient evidence of a difference in cumulative live birth; possible miscarriage reduction on the first transfer only, cumulative data scarce.

Typical cost in India

~₹23,000–30,000 per embryo (some clinics ₹25,000–50,000+ total), on top of base IVF.

Does PGT-A improve my chance of having a baby?
For most patients, no. HFEA rates it red for improving your chance of a baby because it is a selection tool that reduces the embryos available and can lengthen the time to conception; NICE advises not offering it to improve live birth rates.
Is PGT-A ever worthwhile?
It can reduce the chance of miscarriage (HFEA rates it green for that), and the Indian society (ISAR) sees a role for women aged 36–40 or with known-cause recurrent pregnancy loss. It is not recommended for younger, good-prognosis patients.

Sources

Take this further

Sources last reviewed .