Fertility Decoded

EmbryoGlue (hyaluronate-enriched transfer medium)

A transfer fluid containing hyaluronic acid, meant to help the embryo stick.

Written by Fertility Decoded. Reviewed by D R, MS (OBG), FRM. Review date: 31 August 2026.

The verdict

Weak, mixed evidence — ESHRE (and ISAR for recurrent implantation failure) are cautiously in favour; others less so.

Who are these bodies?

HFEA
— UK fertility regulator; rates add-ons by evidence (traffic-light).
ESHRE
— European fertility society; evidence-based practice guidance.
NICE
— UK health-guidance body; what the NHS will and won't fund.
ISAR
— Indian Society for Assisted Reproduction; Indian expert consensus.
Cochrane
— Independent global reviewers of the underlying studies.

  • HFEA

    UK regulator

    Yellow — unclear/conflicting — chance of a baby
    Source

  • ESHRE

    European society

    Recommended

    One of the few add-ons ESHRE recommends (for routine use with fresh transfers).

    Source

  • NICE

    UK NHS guidance

    Not addressed

    Not addressed in the NG257 add-on chapter.

  • ISAR

    Indian society

    May be considered (esp. RIF)

    May be considered a useful transfer medium, particularly in recurrent implantation failure (cites Cochrane update, 16 RCTs, improved live birth, moderate quality).

    Source

  • Cochrane

    Evidence base

    May increase pregnancy/live birth, but the live-birth effect was not robust under a random-effects model.

Typical cost in India

Small add-on, ~₹5,000–15,000 (approximate; usually bundled).

Sources

Take this further

Sources last reviewed .