Fertility Decoded

EmbryoGlue (hyaluronate-enriched transfer medium)

A transfer fluid containing hyaluronic acid, meant to help the embryo stick.

The verdict

Weak, mixed evidence — ESHRE (and ISAR for recurrent implantation failure) are cautiously in favour; others less so.

Evidence positions on EmbryoGlue (hyaluronate-enriched transfer medium) from HFEA, ESHRE, NICE and ISAR
BodyPosition
HFEA
  • Yellow — unclear/conflictingfor chance of a baby
ESHRERecommended

One of the few add-ons ESHRE recommends (for routine use with fresh transfers).

Source
NICENot addressed

Not addressed in the NG257 add-on chapter.

ISARMay be considered (esp. RIF)

May be considered a useful transfer medium, particularly in recurrent implantation failure (cites Cochrane update, 16 RCTs, improved live birth, moderate quality).

Source

Cochrane evidence base

May increase pregnancy/live birth, but the live-birth effect was not robust under a random-effects model.

In India

Small add-on, ~₹5,000–15,000 (approximate; usually bundled).

Sources

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Last reviewed .