Fertility Decoded

IVIG (intravenous immunoglobulin)

An infusion of pooled antibodies given to 'calm' the immune system, in the hope it aids implantation.

The verdict

Not recommended; carries safety concerns.

Evidence positions on IVIG (intravenous immunoglobulin) from HFEA, ESHRE, NICE and ISAR
BodyPosition
HFEA
  • Red — may reduce effectivenessfor chance of a baby
ESHRENot recommended

Not recommended for any group (immunology treatments); potentially serious side-effects.

Source
NICEDo not use (2026)

NG257 1.42.1: do not use immunological agents, including intravenous immunoglobulins, as part of fertility treatment.

Source
ISARNo position

Not addressed in the 2021 ISAR add-ons consensus.

Cochrane evidence base

Meta-analysis of commonly used IVF immunotherapies shows no benefit.

In India

Expensive per infusion; varies.

Sources

Take this further

Last reviewed .