PICSI (physiological ICSI)
Selecting sperm by their ability to bind hyaluronan before injecting them into the egg.
The verdict
No effect on your chance of a baby.
| Body | Position |
|---|---|
| HFEA |
|
| ESHRE | Not for routine use Not recommended for routine clinical use. Source |
| NICE | Not addressed Not addressed in NG257. |
| ISAR | Needs robust RCTs Need robust RCTs to recommend use (cites Cochrane 2018 low-quality; Miller/Lancet 2019: no effect on live birth, HA-ICSI may lower miscarriage). Source |
Cochrane evidence base
Large RCT (HABSelect) found no improvement in live birth.
In India
Charged as an advanced-lab add-on, ~₹10,000–25,000 (varies; often bundled).
Sources
Take this further
Last reviewed .