Fertility Decoded

Sperm DNA fragmentation test

A test of DNA damage in sperm.

The verdict

Evidence unclear; limited routine clinical value.

Evidence positions on Sperm DNA fragmentation test from HFEA, ESHRE, NICE and ISAR
BodyPosition
HFEA
  • Not on HFEA's rated listfor chance of a baby
ESHRENot for routine use

Not recommended for routine clinical use (low-quality, high variability; no way to identify a fragmentation-free sperm for ICSI).

Source
NICENot addressed

Not addressed in NG257.

ISARNot routine; indicated in specific cases

Not a routine test for all patients; a recommended indication for ICSI failure and male age over 40; a possible indication for repeated IUI/IVF failure and adverse lifestyle.

Source

In India

Charged as an add-on test; varies by clinic.

Sources

Take this further

Last reviewed .